Human CD63 Full Length Protein, Flag, His Tag (Detergent)

Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.

Product Specifications

Background

Specifications

This protein carries a flag tag at the N-terminus and a polyhistidine tag at the C-terminus. The protein has a calculated MW of 29.6 kDa.

Accession Number

P08962

Expression Region

Ala 2 - Met 238

Host

Insect Cells

Target

CD63

Conjugation

Unconjugated

Tag

N-Flag & C-10xHis

Source

Human

Stability

The product MUST be stored at -70°C or lower upon receipt; -70°C for 3 months under sterile conditions.

Endotoxin

1.0 EU per μg

Bioactivity

Immobilized Human CD63 Full Length Protein, Flag,His Tag (Cat. No. CD3-H55D3) at 1 μg/mL (100 μL/well) can bind Anti-CD63 Antibody with a linear range of 1-31 ng/mL (QC tested).