INCB3344 (R-isomer)
INCB3344 R-isomer is the R-isomer of INCB3344. INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity[1].
Product Specifications
UNSPSC
12352005
Target
CCR
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/INCB3344_R-isomer.html
Concentration
10mM
Purity
98.01
Solubility
DMSO : ≥ 106.5 mg/mL
Smiles
CCO[C@H]1CN([C@]2([H])CC[C@](C3=CC(OCO4)=C4C=C3)(O)CC2)C[C@@H]1NC(CNC(C5=CC(C(F)(F)F)=CC=C5)=O)=O
Molecular Formula
C29H34F3N3O6
Molecular Weight
577.59
References & Citations
[1]Xue CB, et al. Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2. Bioorg Med Chem Lett. 2010 Dec 15;20 (24) :7473-8
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2
Available Sizes
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