HGPR91 antagonist 3
HGPR91 antagonist 3 (Compound 5g) is a potent and orally active GPR91 antagonist with IC50s of 35 nM and 135 nM, for human GPR91 and rat GPR91, respectively[1].
Product Specifications
CAS Number
[1314796-31-0]
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Succinate Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hgpr91-antagonist-3.html
Concentration
10mM
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(CCCC1=CC=C2C=CC=NC2=N1)NCC3=CC(C4=CC(C(F)(F)F)=C(F)C=C4)=NO3
Molecular Formula
C23H18F4N4O2
Molecular Weight
458.41
Precautions
H315, H319, H335
References & Citations
[1]Bhuniya D, et al. Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett. 2011;21 (12) :3596-3602.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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