Doxepin-d3 (hydrochloride)

Doxepin-d3 (hydrochloride) is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

Product Specifications

CAS Number

[347840-07-7]

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H361, H362, H410

Target

Cytochrome P450; Histamine Receptor

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Purity

99.88

Solubility

10 mM in DMSO

Smiles

[2H]C(N(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C\13)([2H])[2H].[H]Cl

Molecular Formula

C19H19D3ClNO

Molecular Weight

318.86

Precautions

H301, H311, H331, H361, H362, H410

References & Citations

[1]Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62 (6) : p. 453-63.|[2]Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151 (6) :737-48.