Closantel-13C6

Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

Product Specifications

CAS Number

[1325559-20-3]

UNSPSC

12352005

Hazard Statement

H301-H413

Target

Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/closantel-13c6.html

Solubility

10 mM in DMSO

Smiles

N#CC(C(C=C1)=CC=C1Cl)C(C=C2C)=C(C=C2NC([13C]([13CH]=[13C]3I)=[13C]([13C](I)=[13CH]3)O)=O)Cl

Molecular Formula

C16 13C6H14Cl2I2N2O2

Molecular Weight

669.03

Precautions

P264-P270-P273-P330-P405-P501

References & Citations

[1]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54 (11) :3963-72.|[2]Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54 (11) :3963-72.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.