Carboxymethyl chitosan

Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[83512-85-0]

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Bcl-2 Family; Biochemical Assay Reagents; Caspase; Reactive Oxygen Species (ROS)

Type

Biochemical Assay Reagents

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/carboxymethyl-chitosan.html

Purity

Solubility

H2O : 10 mg/mL (ultrasonic)

Smiles

[Carboxymethylchitosan]

Precautions

H302, H315, H319, H335

References & Citations

[1]Chen XG, et al. The effect of carboxymethyl-chitosan on proliferation and collagen secretion of normal and keloid skin fibroblasts. Biomaterials. 2002 Dec;23 (23) :4609-14.|[2]Kruczkowska W, et al. Medical Applications and Cellular Mechanisms of Action of Carboxymethyl Chitosan Hydrogels. Molecules. 2024 Sep 13;29 (18) :4360.|[3]He B, et al. Carboxymethylated chitosan protects Schwann cells against hydrogen peroxide-induced apoptosis by inhibiting oxidative stress and mitochondria dependent pathway. Eur J Pharmacol. 2018 Apr 15;825:48-56.|[4]Jiang Z, et al. Carboxymethyl chitosan represses tumor angiogenesis in vitro and in vivo. Carbohydr Polym. 2015 Sep 20;129:1-8.|[5]Chen Q, et al. Carboxymethyl-chitosan protects rabbit chondrocytes from interleukin-1beta-induced apoptosis. Eur J Pharmacol. 2006 Jul 10;541 (1-2) :1-8.|[6]Jiang Z, et al. Evaluation on biological compatibility of carboxymethyl chitosan as biomaterials for antitumor drug delivery. J Biomater Appl. 2017 Feb;31 (7) :985-994.|[7]Jiang Z, et al. Preparation and anti-tumor metastasis of carboxymethyl chitosan. Carbohydr Polym. 2015 Jul 10;125:53-60.|[8]Yang Z, et al. Acute toxicity of high dosage carboxymethyl chitosan and its effect on the blood parameters in rats. J Mater Sci Mater Med. 2012 Feb;23 (2) :457-62.