Mirogabalin
Product Specifications
Product Name Alternative
DS5565
UNSPSC Description
Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS.
Target Antigen
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Mirogabalin.html
Purity
99.31
Solubility
DMSO : < 1 mg/mL|H2O : 7.71 mg/mL (ultrasonic)
Smiles
O=C(O)C[C@]1(CN)[C@]2([H])C=C(CC)C[C@]2([H])C1
Molecular Weight
209.289
References & Citations
[1]Vinik A, et al. Efficacy and safety of Mirogabalin (DS-5565) for the treatment of diabetic peripheral neuropathic pain: a randomized, double-blind, placebo- and active comparator-controlled, adaptive proof-of-concept phase 2 study. Diabetes Care. 2014 Dec|[2]Hutmacher MM, et al. Exposure-response modeling of average daily pain score, and dizziness and somnolence, forMirogabalin (DS-5565) in patients with diabetic peripheral neuropathic pain. J Clin Pharmacol. 2016 Jan;56(1):67-77.Brain Behav Immun. 2021 Jul;95:344-361.|Molecules. 2023 Nov 30, 28(23), 7862.|Pharmaceuticals. 2022, 15(1), 88.|Pharmaceuticals. 2023 Jul 19, 16(7), 1023.|Cell Commun Signal. 2024 Feb 1;22(1):92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12650/Mirogabalin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12650/Mirogabalin-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
1138245-13-2
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
