(R) -SKBG-1
(R) -SKBG-1 is a covalent inhibitor targeting the RNA binding protein NONO. (R) -SKBG-1 can reduce the expression of androgen receptor (AR) and its splice variants, inhibiting cancer cell proliferation. (R) -SKBG-1 inhibits androgen receptor expression with IC50 of 3.1 μM and 5.5 μM for AR-FL mRNA and AR-V7 mRNA, respectively. (R) -SKBG-1 interferes with the gene regulatory network of cancer cells and inhibits cancer cell growth by stabilizing the interaction between NONO and mRNA. (R) -SKBG-1 can be used in the study of cancers related to NONO dysfunction, such as prostate cancer[1][2][3].
Product Specifications
CAS Number
2955634-67-8
UNSPSC
12352005
Target
Androgen Receptor
Type
Reference compound
Related Pathways
Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/r-skbg-1.html
Purity
99.50
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=S(N1[C@@H](C(NCC2=CC=C(OC)C=C2)=O)CN(C(CCl)=O)CC1)(C3=CC=C(OC)C=C3)=O
Molecular Formula
C22H26ClN3O6S
Molecular Weight
495.98
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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