2,5-Dimethylcelecoxib

2,5-Dimethylcelecoxib is an analogue of celecoxib (HY-14398) with anticancer activity but without COX-2 inhibitory activity. 2,5-Dimethylcelecoxib exerts its anti-cancer cell proliferation effect by inhibiting the core mechanism of the Wnt/β-catenin signaling pathway. 2,5-Dimethylcelecoxib also inhibits T-cell factor-dependent transcriptional activity and inhibits expression of the Wnt/β-catenin target gene products cyclin D1 and survivin[1].

Product Specifications

CAS Number

[457639-26-8]

UNSPSC

12352005

Hazard Statement

H301

Target

Survivin; Wnt; β-catenin

Type

Reference compound

Related Pathways

Apoptosis; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/2-5-dimethylcelecoxib.html

Purity

99.57

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=CC=C(N2N=C(C(F)(F)F)C=C2C3=CC(C)=CC=C3C)C=C1)(N)=O

Molecular Formula

C18H16F3N3O2S

Molecular Weight

395.40

Precautions

H301

References & Citations

[1]Egashira I, et al. Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway. Cancer Sci. 2017 Jan;108 (1) :108-115.