MRT68921 (dihydrochloride)
MRT68921 dihydrochloride is a potent NUAK1/ULK1 dual inhibitor. MRT68921 dihydrochloride inhibits ULK1 and ULK2 with IC50 values of 2.9 nM and 1.1 nM, respectively. MRT68921 dihydrochloride can block cells autophagy and kill tumor cells by breaking the balance of oxidative stress signals. MRT68921 dihydrochloride can inhibit cell proliferation and induce ROS production and apoptosis. MRT68921 dihydrochloride can be used for the research of cancer, such as breast cancer[1][2].
Product Specifications
CAS Number
2080306-21-2
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Bcl-2 Family; GSK-3; Reactive Oxygen Species (ROS) ; ULK
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MRT68921-hydrochloride.html
Concentration
10mM
Purity
99.67
Solubility
DMSO : 8.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
[H]Cl.O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5.[H]Cl
Molecular Formula
C25H36Cl2N6O
Molecular Weight
507.50
Precautions
H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-2; GSK-3β; ULK1; ULK2
Citation 01
Available Sizes
Frequently Asked Questions
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