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SHP836

SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2[1].

Product Specifications

CAS Number

1957276-35-5

UNSPSC

12352005

Target

Phosphatase; SHP2

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/shp836.html

Purity

99.39

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

NC1=NC(N2C[C@@H](C)N[C@@H](C)C2)=NC=C1C3=CC=CC(Cl)=C3Cl

Molecular Formula

C16H19Cl2N5

Molecular Weight

352.26

References & Citations

[1]Liu WS, et al. Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation. J Comput Aided Mol Des. 2019 Aug;33 (8) :759-774.|[2]Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59 (17) :7773-82.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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