SHP836
SHP836 is a SHP2 allosteric inhibitor, with an IC50 of 12 μM for the full length SHP2[1].
Product Specifications
CAS Number
1957276-35-5
UNSPSC
12352005
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/shp836.html
Purity
99.39
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
NC1=NC(N2C[C@@H](C)N[C@@H](C)C2)=NC=C1C3=CC=CC(Cl)=C3Cl
Molecular Formula
C16H19Cl2N5
Molecular Weight
352.26
References & Citations
[1]Liu WS, et al. Structure based design of selective SHP2 inhibitors by De novo design, synthesis and biological evaluation. J Comput Aided Mol Des. 2019 Aug;33 (8) :759-774.|[2]Garcia Fortanet J, et al. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. J Med Chem. 2016 Sep 8;59 (17) :7773-82.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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