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NLRP3-IN-42

NLRP3-IN-42 (compound H28) is a potent NLRP3 inhibitor with an KD value of 1.15 µM. NLRP3-IN-42 decreases the LPS induced protein expression of cleaved-caspase-1 (p20). NLRP3-IN-42 selectively inhibits IL-1β release[1].

Product Specifications

UNSPSC

12352005

Target

Interleukin Related; NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-in-42.html

Smiles

CCCNS(=O)(C1=CC=C(C2=CC=CC=C2N(CC3=CC=C(C(F)(F)F)C=C3)C(CC4=CSC=C4)=O)C=C1)=O

Molecular Formula

C29H27F3N2O3S2

Molecular Weight

572.66

References & Citations

[1]Huang C, et al. Discovery of novel biphenyl-sulfonamide analogues as NLRP3 inflammasome inhibitors. Bioorg Chem. 2024 May;146:107263.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-1; NLRP3

Frequently Asked Questions

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