NLRP3-IN-42
NLRP3-IN-42 (compound H28) is a potent NLRP3 inhibitor with an KD value of 1.15 µM. NLRP3-IN-42 decreases the LPS induced protein expression of cleaved-caspase-1 (p20). NLRP3-IN-42 selectively inhibits IL-1β release[1].
Product Specifications
UNSPSC
12352005
Target
Interleukin Related; NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-in-42.html
Smiles
CCCNS(=O)(C1=CC=C(C2=CC=CC=C2N(CC3=CC=C(C(F)(F)F)C=C3)C(CC4=CSC=C4)=O)C=C1)=O
Molecular Formula
C29H27F3N2O3S2
Molecular Weight
572.66
References & Citations
[1]Huang C, et al. Discovery of novel biphenyl-sulfonamide analogues as NLRP3 inflammasome inhibitors. Bioorg Chem. 2024 May;146:107263.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; NLRP3
Frequently Asked Questions
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