CC-401 (hydrochloride)
Product Specifications
Product Name Alternative
CC401 HCl
UNSPSC Description
CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.
Target Antigen
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CC-401-hydrochloride.html
Purity
99.35
Solubility
DMSO : 100 mg/mL (ultrasonic)|H2O : 12.5 mg/mL (ultrasonic)
Smiles
C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5.Cl
Molecular Weight
424.93
References & Citations
[1]Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18(2):472-84.|[2]Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21(18):4143-52.|[3]Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89(4):470-84.Harvard Medical School LINCS LIBRARY|Science. 2017 Dec 1;358(6367):eaan4368.|Cell Syst. 2018 Apr 25;6(4):424-443.e7.|J Med Chem. 2023 Mar 6.|Mol Cancer Res. 2016 Aug;14(8):753-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-13022/CC-401-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13022/CC-401-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
Phase 1
CAS Number
1438391-30-0
Available Sizes
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