N-Boc-dolaproine-amide-Me-Phe

N-Boc-dolaproine-amide-Me-Phe is the amino acid residue of the pentapeptide Dolastatin 10 (HY-15580) . Dolastatin 10 inhibits tubulin polymerization and mitosis and has anticancer activity[1].

Product Specifications

CAS Number

[3026596-72-2]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Microtubule/Tubulin; Mitosis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n-boc-dolaproine-amide-me-phe.html

Concentration

10mM

Purity

98.46

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(N1[C@@H](CCC1)[C@@H]([C@@H](C)C(N[C@@H](C)CC2=CC=CC=C2)=O)OC)OC(C)(C)C

Molecular Formula

C23H36N2O4

Molecular Weight

404.54

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Almeida W P, et al. An easy and stereoselective synthesis of N-Boc-dolaproine via the Baylis–Hillman reaction[J]. Tetrahedron letters, 2003, 44 (5) : 937-940.