Dehydrocrenatine
Dehydrocrenatidine, a β-carboline alkaloid that can be isolated from Picrasma quassioides. Dehydrocrenatidine induces cell apoptosis by activates ERK and JNK. Dehydrocrenatidine inhibits invasion and migration of cancer cells, it also suppresses neuronal excitability to exert analgesic effects[1][2].
Product Specifications
CAS Number
26585-13-7
UNSPSC
12352005
Target
Apoptosis; ERK; JNK
Type
Natural Products
Related Pathways
Apoptosis; MAPK/ERK Pathway; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/dehydrocrenatine.html
Solubility
10 mM in DMSO
Smiles
COC1=CN=C(C=C)C(N2)=C1C3=C2C=CC=C3
Molecular Formula
C14H12N2O
Molecular Weight
224.26
References & Citations
[1]Ho HY, et al. Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. Biomed Pharmacother. 2021 May;137:111362.|[2]Hsieh MC, et al. Dehydrocrenatidine extracted from Picrasma quassioidesinduces the apoptosis of nasopharyngeal carcinoma cells through the JNK and ERK signaling pathways. Oncol Rep. 2021 Aug;46 (2) :166.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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