Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Oritavancin (diphosphate)

Oritavancin diphosphate (LY333328 diphosphate), a semisynthetic derivative of Vancomycin , is an orally active glycopeptide antibiotic with bactericidal activity against gram-positive organisms. Oritavancin diphosphate shows antibacterial effect against B. anthracis, such as Ames strain with a MIC value of 0.015 g/mL. Oritavancin diphosphate inhibits cell wall synthesis and disrupts the membrane potential. Oritavancin diphosphate inhibits ArlS kinase activity thereby interfering the signal transduction. Oritavancin diphosphate enters cells by adsorptive endocytosis, which drives it to lysosomes, where it exerts antibiotic activity[1][2][3][4][5].

Product Specifications

CAS Number

192564-14-0

Product Name Alternative

LY333328 diphosphate

UNSPSC

12352005

Hazard Statement

H317

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Oritavancin-diphosphate.html

Purity

99.93

Solubility

DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@]2(C)NCC3=CC=C(C4=CC=C(Cl)C=C4)C=C3)[C@@H](O[C@H](CO)[C@H]1O)OC5=C(OC6=CC=C([C@H]([C@H]7NC([C@H](NC)CC(C)C)=O)O)C=C6Cl)C=C([C@](NC([C@@H](NC7=O)CC(N)=O)=O)([H])C(N[C@](C8=O)([H])C9=CC%10=C(O)C=C9)=O)C=C5OC%11=CC=C([C@H]([C@](C(N[C@@](C(O)=O)([H])C%12=C%10C(O)=CC(O)=C%12)=O)([H])N8)O[C@@](O[C@@H](C)[C@@H]%13O)([H])C[C@@]%13(N)C)C=C%11Cl.O=P(O)(O)O.O=P(O)(O)O

Molecular Formula

C86H103Cl3N10O34P2

Molecular Weight

1989.09

Precautions

H317

References & Citations

[1]Arhin FF, et al. Effect of polysorbate 80 on oritavancin binding to plastic surfaces: implications for susceptibility testing. Antimicrob Agents Chemother. 2008 May;52 (5) :1597-1603.|[2]Coyle EA, et al. Activity of oritavancin (LY333328), an investigational glycopeptide, compared to that of vancomycin against multidrug-resistant Streptococcus pneumoniae in an in vitro pharmacodynamic model. Antimicrob Agents Chemother. 2001 Mar;45 (3) :706-9.|[3]Bai J, et al. The role of ArlRS in regulating oxacillin susceptibility in methicillin-resistant Staphylococcus aureus indicates it is a potential target for antimicrobial resistance breakers[J]. Emerg Microbes Infect. 2019;8 (1) :503-515.|[4]Van Bambeke F, et al. Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages[J]. Antimicrob Agents Chemother. 2004 Aug;48 (8) :2853-60.|[5]Heine HS, et al. Efficacy of oritavancin in a murine model of Bacillus anthracis spore inhalation anthrax. Antimicrob Agents Chemother. 2008 Sep;52 (9) :3350-7.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

Glycopeptide

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Rabbit Polyclonal CHML Antibody [DyLight 594]
NBP2-98162DL594 0.1 mL

Rabbit Polyclonal CHML Antibody [DyLight 594]

Sign In for Pricing
View Details
Mouse Monoclonal MMP-15/MT2-MMP Antibody (MM0028-5D11) [HRP]
NB110-60994H 0.1 mL

Mouse Monoclonal MMP-15/MT2-MMP Antibody (MM0028-5D11) [HRP]

Sign In for Pricing
View Details
UBE2L3 3'UTR Luciferase Stable Cell Line
TU027666 1.0 mL

UBE2L3 3'UTR Luciferase Stable Cell Line

Sign In for Pricing
View Details
Rat Kcnj5 Pre-designed siRNA Set B
SI207100B 1 Each

Rat Kcnj5 Pre-designed siRNA Set B

Sign In for Pricing
View Details
SP Assay Kit (UV Spectrophotometry)
orb3132113 50 Tests

SP Assay Kit (UV Spectrophotometry)

Sign In for Pricing
View Details
MFAP4 (NM_001198695) Human Tagged ORF Clone
RG231122 10 µg

MFAP4 (NM_001198695) Human Tagged ORF Clone

Sign In for Pricing
View Details