Longestin

Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent[1][2].

Product Specifications

CAS Number

[131774-53-3]

Product Name Alternative

KS-505a

UNSPSC

12352005

Target

Parasite; Phosphodiesterase (PDE)

Type

Natural Products

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/longestin.html

Smiles

OC[C@@]12[C@]3([H])[C@]([C@@]4([H])[C@](CC3)(OC5=CC=C(C(O)(OC6=O)CCC(OC)=O)C6=C5C4)CO)(CC[C@@]1([H])[C@]7([C@]([C@@]8([C@@]([C@]9([C@]([C@@]%10([C@@]([C@](C)([C@H](C[C@H]%10C)O[C@H]%11[C@@H]([C@H]([C@@H]([C@H](O%11)C(O)=O)O)O)OC)C(O)=O)([H])CC9)C)([H])C[C@H]8C)C)([H])CC7)C)([H])CC2)C)C

Molecular Formula

C61H88O17

Molecular Weight

1093.34

References & Citations

[1]Ozaki T, et al. Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a) : Involvement of Homo-IPP as a Common Extender Unit. Angew Chem Int Ed Engl. 2018 May 28;57 (22) :6629-6632.|[2]Hayashi Y, et al. Cloning of the gene cluster responsible for biosynthesis of KS-505a (longestin), a unique tetraterpenoid. Biosci Biotechnol Biochem. 2007 Dec;71 (12) :3072-81.