Longestin
Longestin (KS-505a) is a specific inhibitor of phosphodiesterase with antitrypanosomal activity, which is derived from Streptomyces argenteolus. Longestin is promising for research of anti-amnesia agent[1][2].
Product Specifications
CAS Number
131774-53-3
Product Name Alternative
KS-505a
UNSPSC
12352005
Target
Parasite; Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/longestin.html
Smiles
OC[C@@]12[C@]3([H])[C@]([C@@]4([H])[C@](CC3)(OC5=CC=C(C(O)(OC6=O)CCC(OC)=O)C6=C5C4)CO)(CC[C@@]1([H])[C@]7([C@]([C@@]8([C@@]([C@]9([C@]([C@@]%10([C@@]([C@](C)([C@H](C[C@H]%10C)O[C@H]%11[C@@H]([C@H]([C@@H]([C@H](O%11)C(O)=O)O)O)OC)C(O)=O)([H])CC9)C)([H])C[C@H]8C)C)([H])CC7)C)([H])CC2)C)C
Molecular Formula
C61H88O17
Molecular Weight
1093.34
References & Citations
[1]Ozaki T, et al. Enzymatic Formation of a Skipped Methyl-Substituted Octaprenyl Side Chain of Longestin (KS-505a) : Involvement of Homo-IPP as a Common Extender Unit. Angew Chem Int Ed Engl. 2018 May 28;57 (22) :6629-6632.|[2]Hayashi Y, et al. Cloning of the gene cluster responsible for biosynthesis of KS-505a (longestin), a unique tetraterpenoid. Biosci Biotechnol Biochem. 2007 Dec;71 (12) :3072-81.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Frequently Asked Questions
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