MK-3903
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
Product Specifications
CAS Number
1219737-12-8
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
AMPK
Type
Reference compound
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/MK-3903.html
Purity
98.03
Solubility
DMSO : ≥ 100 mg/mL
Smiles
ClC1=CC2=C(NC(OC3=CC=C(C)C(C(O)=O)=C3)=N2)C=C1C(C=C4)=CC=C4C5=CC=CC=C5
Molecular Formula
C27H19ClN2O3
Molecular Weight
454.90
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Lan P, Romero FA, et al. Hit-to-Lead Optimization and Discovery of 5- ((5- ([1,1'-Biphenyl]-4-yl) -6-chloro-1H-benzo[d]imidazol-2-yl) oxy) -2-methylbenzoic Acid (MK-3903) : A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase. J Med Chem. 2017 Nov 9;60 (21) :9040-9052.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK
Available Sizes
Frequently Asked Questions
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