MK-3903

MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.

Product Specifications

CAS Number

[1219737-12-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

AMPK

Type

Reference compound

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/MK-3903.html

Purity

98.03

Solubility

DMSO : ≥ 100 mg/mL

Smiles

ClC1=CC2=C(NC(OC3=CC=C(C)C(C(O)=O)=C3)=N2)C=C1C(C=C4)=CC=C4C5=CC=CC=C5

Molecular Formula

C27H19ClN2O3

Molecular Weight

454.90

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Lan P, Romero FA, et al. Hit-to-Lead Optimization and Discovery of 5- ((5- ([1,1'-Biphenyl]-4-yl) -6-chloro-1H-benzo[d]imidazol-2-yl) oxy) -2-methylbenzoic Acid (MK-3903) : A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase. J Med Chem. 2017 Nov 9;60 (21) :9040-9052.