FEMA 4809
FEMA 4809 is a TRPM8 receptor agonist (EC50=0.2 nM) for use as a cooling agent. TRPM8 is the ion channel responsible for the cool perception[1].
Product Specifications
CAS Number
[1374760-95-8]
UNSPSC
12352005
Hazard Statement
H317, H411
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/fema-4809.html
Purity
99.25
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(N(C1=NNC=C1)CC2=CC=CS2)COC3=CC=C(C)C=C3
Molecular Formula
C17H17N3O2S
Molecular Weight
327.40
Precautions
H317, H411
References & Citations
[1]Alain Noncovich, et al. Discovery and development of a novel class of phenoxyacetyl amides as highly potent TRPM8 agonists for use as cooling agents. Bioorg Med Chem Lett. 2017 Aug 15;27 (16) :3931-3938.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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