11 ß-HSD1 CRISPR Plasmids

<strong>11 ß-HSD1 CRISPR Plasmids</strong>_x000D_ <strong>Catalog number:</strong> B2015183_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ¬µg_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2 - 8 ¬∞C_x000D_ <strong>Keywords:</strong> 11 ß-HSD1 CRISPR Plasmids_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Akalestou E, Lopez-Noriega L, Christakis I, Hu M, Miras AD, Leclerc I, Rutter GA. Vertical sleeve gastrectomy normalizes circulating glucocorticoid levels and lowers glucocorticoid action tissue-selectively in mice Front Endocrinol (Lausanne). 2022 Sep 29;13:1020576._x000D_ 2: Kragl A, Schoon J, Tzvetkova A, Wenzel C, Blaschke M, B√∂cker W, Siggelkow H, Tzvetkov MV. Effects of HSD11B1 knockout and overexpression on local cortisol production and differentiation of mesenchymal stem cells Front Bioeng Biotechnol. 2022 Aug 25;10:953034._x000D_ 3: Brooks K, Burns G, Spencer TE. Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation Biol Reprod. 2015 Aug;93(2):38._x000D_ 4: Taves MD, Otsuka S, Taylor MA, Donahue KM, Meyer TJ, Cam MC, Ashwell JD. Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth J Clin Invest. 2023 Sep 15;133(18):e164599._x000D_ 5: Chuanxin Z, Shengzheng W, Lei D, Duoli X, Jin L, Fuzeng R, Aiping L, Ge Z. Progress in 11 ß-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development Eur J Med Chem. 2020 Apr 1;191:112134._x000D_ 6: Gray GA, White CI, Castellan RF, McSweeney SJ, Chapman KE. Getting to the heart of intracellular glucocorticoid regeneration: 11 ß-HSD1 in the myocardium J Mol Endocrinol. 2017 Jan;58(1):R1-R13._x000D_ 7: Leiva R, McBride A, Binnie M, Webster SP, V√°zquez S. Exploring N-acyl-4-azatetracyclo[5.3.2.0(2,6).0(8,10)]dodec-11-enes as 11 ß-HSD1 Inhibitors Molecules. 2018 Feb 28;23(3):536._x000D_ 8: Morgan SA, Gathercole LL, Hassan-Smith ZK, Tomlinson J, Stewart PM, Lavery GG. 11 ß-HSD1 contributes to age-related metabolic decline in male mice J Endocrinol. 2022 Oct 7;255(3):117-129._x000D_ 9: Chapman KE, Seckl JR. 11beta-HSD1, inflammation, metabolic disease and age-related cognitive (dys)function Neurochem Res. 2008 Apr;33(4):624-36._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/29385440">10: Wang W, Chen ZJ, Myatt L, Sun K. 11 ß-HSD1 in Human Fetal Membranes as a Potential Therapeutic Target for Preterm Birth Endocr Rev. 2018 Jun 1;39(3):241-260. </a>_x000D_ _x000D_ <strong>Products Related to 11 ß-HSD1 CRISPR Plasmids can be found at</strong> <a href="https://moleculardepot.com/product-category/DNA/"> DNA</a>