Dapansutrile
Dapansutrile is a potent, orally active and selective NLRP3 inflammasome inhibitor. Dapansutrile has anti-inflammatory activity and decreases immune factor levels. Dapansutrile can be used for research of inflammatory diseases[1][2].
Product Specifications
CAS Number
54863-37-5
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/Dapansutrile.html
Concentration
10mM
Purity
99.92
Solubility
DMSO : ≥ 100 mg/mL|H2O : 36.67 mg/mL (ultrasonic)
Smiles
N#CCCS(=O)(C)=O
Molecular Formula
C4H7NO2S
Molecular Weight
133.17
Precautions
H302, H315, H319, H335
References & Citations
[1]Sánchez-Fernández A, et, al. OLT1177 (Dapansutrile), a Selective NLRP3 Inflammasome Inhibitor, Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Front Immunol. 2019 Nov 1;10:2578.|[2]Toldo S, et, al. The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse. J Cardiovasc Pharmacol. 2019 Apr;73 (4) :215-222.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
NLRP3
Available Sizes
Frequently Asked Questions
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