JNK3 inhibitor-1
JNK3 inhibitor-1 is a potent and selective JNK3 inhibitor (IC50 = 0.005 μM) . JNK3 inhibitor-1 is orally bioavailable and brain penetrant.
Product Specifications
CAS Number
[2622877-97-6]
UNSPSC
12352005
Target
JNK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/jnk3-inhibitor-1.html
Concentration
10mM
Purity
98.15
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(N2N=CC3=CC(NC4=C(F)C=CC=C4Cl)=C(C)N=C32)=CS1)NC5COC5
Molecular Formula
C21H17ClFN5O2S
Molecular Weight
457.91
References & Citations
[1]Feng Y, et al. N-Aromatic-Substituted Indazole Derivatives as Brain-Penetrant and Orally Bioavailable JNK3 Inhibitors. ACS Med Chem Lett. 2021 Sep 21;12 (10) :1546-1552.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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