[6]-Gingerol
[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.
Product Specifications
CAS Number
23513-14-6
Product Name Alternative
(S) - (+) -[6]Gingerol
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
AMPK; Apoptosis
Type
Natural Products
Related Pathways
Apoptosis; Epigenetics; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/[6]-Gingerol.html
Concentration
10mM
Purity
99.68
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O
Molecular Formula
C17H26O4
Molecular Weight
294.39
Precautions
H301, H315, H319, H335
References & Citations
[1]Radhakrishnan EK, et al. [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9 (8) :e104401.|[2]Chang KW, et al. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS) -treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6 (10) :3334-41.|[3]Fan J, et al. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol. 2015 Feb;36 (2) :1135-41.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
AMPK
Available Sizes
Frequently Asked Questions
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