[6]-Gingerol

[6]-Gingerol is an active compound isolated from Ginger (Zingiber officinale), exhibits a variety of biological activities including anticancer, anti-inflammation, and anti-oxidation.

Product Specifications

CAS Number

[23513-14-6]

Product Name Alternative

(S) - (+) -[6]Gingerol

UNSPSC

12352005

Hazard Statement

H301, H315, H319, H335

Target

AMPK; Apoptosis

Type

Natural Products

Related Pathways

Apoptosis; Epigenetics; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/[6]-Gingerol.html

Concentration

10mM

Purity

99.68

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CCCCC[C@H](O)CC(CCC1=CC=C(O)C(OC)=C1)=O

Molecular Formula

C17H26O4

Molecular Weight

294.39

Precautions

H301, H315, H319, H335

References & Citations

[1]Radhakrishnan EK, et al. [6]-Gingerol induces caspase-dependent apoptosis and prevents PMA-induced proliferation in colon cancer cells by inhibiting MAPK/AP-1 signaling. PLoS One. 2014 Aug 26;9 (8) :e104401.|[2]Chang KW, et al. 6-Gingerol modulates proinflammatory responses in dextran sodium sulfate (DSS) -treated Caco-2 cells and experimental colitis in mice through adenosine monophosphate-activated protein kinase (AMPK) activation. Food Funct. 2015 Oct;6 (10) :3334-41.|[3]Fan J, et al. 6-Gingerol inhibits osteosarcoma cell proliferation through apoptosis and AMPK activation. Tumour Biol. 2015 Feb;36 (2) :1135-41.