ML148
ML148 is a potent and selective 15-PGDH inhibitor with an IC50 of 56 nM. ML148 has the potential for the research of prostaglandin-signaling pathways[1].
Product Specifications
CAS Number
[451496-96-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
15-PGDH
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ml148.html
Purity
99.77
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C(N1CCCCC1)C2=CC=C3N(C=NC3=C2)C4=CC=CC(C)=C4
Molecular Formula
C20H21N3O
Molecular Weight
319.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Niesen FH, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS One. 2010 Nov 2;5 (11) :e13719.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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