AmmTX3 (TFA)
AmmTX3 TFA is a peptide toxin that can be isolated from the venom of the scorpion Androctonus mauretanicus. AmmTX3 TFA is specific blocker of Kv4 channel. AmmTX3 TFA inhibits the A-type K+ current (Ki: 131 nM) [1][2].
Product Specifications
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ammtx3-tfa.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@@H](N1)CCC1=O)=O)[C@H](CC)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]2CCCCN)=O)=O)C)=O)C)=O)C(C)C)=O)=O)[C@H](CC)C)=O)C(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CSSC[C@H](NC3=O)C(N[C@H](C(N4[C@H](C(O)=O)CCC4)=O)CC5=CC=C(O)C=C5)=O)=O)C(C)C)=O)CO)=O)C)=O)CSSC[C@H](NC6=O)C(N[C@H]3C(C)C)=O)=O)CO)=O)=O)=O)CCC(N)=O)=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(NCC(N[C@H]6CCCNC(N)=N)=O)=O)CC(N)=O)=O)[C@H](CC)C)=O)=O)CCCCN)=O)CCCCN)=O)CC(N)=O)=O)[C@@H](C)O)=O)CCC(O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C158H262N50O48S6.xC2HF3O2
Molecular Weight
3822.47 (free acid)
References & Citations
[1]Vacher H, et al. Expanding the scorpion toxin alpha-KTX 15 family with AmmTX3 from Androctonus mauretanicus. Eur J Biochem. 2002 Dec;269 (24) :6037-41. https://|[2]Maffie JK, et al. Dipeptidyl-peptidase-like-proteins confer high sensitivity to the scorpion toxin AmmTX3 to Kv4-mediated A-type K+ channels. J Physiol. 2013 May 15;591 (10) :2419-27.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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