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TLR7/8 agonist 1 (dihydrochloride)

TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline[1][2].

Product Specifications

CAS Number

1620278-72-9

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/TLR7-8_agonist_1_dihydrochloride.html

Purity

99.70

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=C(CN)C=C4.[H]Cl.[H]Cl

Molecular Formula

C22H27Cl2N5

Molecular Weight

432.39

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Shukla NM, et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20 (22) :6384-6.|[2]Beesu M, et al. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J Med Chem. 2015 Oct 8;58 (19) :7833-49.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

TLR7; TLR8

Available Sizes

Frequently Asked Questions

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