TLR7/8 agonist 1 (dihydrochloride)
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline[1][2].
Product Specifications
CAS Number
1620278-72-9
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/TLR7-8_agonist_1_dihydrochloride.html
Purity
99.70
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
NC1=NC2=CC=CC=C2C3=C1N=C(CCCC)N3CC4=CC=C(CN)C=C4.[H]Cl.[H]Cl
Molecular Formula
C22H27Cl2N5
Molecular Weight
432.39
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Shukla NM, et al. Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7. Bioorg Med Chem Lett. 2010 Nov 15;20 (22) :6384-6.|[2]Beesu M, et al. Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity. J Med Chem. 2015 Oct 8;58 (19) :7833-49.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR7; TLR8
Available Sizes
Frequently Asked Questions
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