Docetaxal

Docetaxal (10-Acetyl docetaxel) is an analog of Docetaxel (HY-B0011), with anticancer activity. Docetaxel is a microtubule disassembly inhibitor, with antimitotic activity[1][2].

Product Specifications

CAS Number

[125354-16-7]

Product Name Alternative

10-Acetyl docetaxel; PNU-101383

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Payload

Type

Reference compound

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/docetaxal.html

Purity

99.54

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(O[C@@]1([C@](C2)([H])OC1)[C@@]([C@](C([C@@H]3OC(C)=O)=O)([C@H]2O)C)([H])[C@@H]([C@@](C(C)(C3=C4C)C)(C[C@@H]4OC([C@H](O)[C@H](C5=CC=CC=C5)NC(OC(C)(C)C)=O)=O)O)OC(C6=CC=CC=C6)=O)=O

Molecular Formula

C45H55NO15

Molecular Weight

849.92

Precautions

H302, H315, H319, H335

References & Citations

[1]Gueritte-Voegelein, et al. Relationships between the structure of taxol analogs and their antimitotic activity. Journal of Medicinal Chemistry, 1991. 34 (3), 992–998.|[2]Yao, Peng, et al. Preparation of crystal form of dihydrate and DMSO solvate of anticancer compound CX1409. CN107793382A.