PLX7904
PLX7904 is a potent and selective BRAF inhibitor, with IC50 of appr 5 nM against BRAFV600E in mutant RAS expressing cells.
Product Specifications
CAS Number
[1393465-84-3]
Product Name Alternative
PB04
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Raf
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PLX7904.html
Purity
98.94
Solubility
DMSO : ≥ 30 mg/mL
Smiles
O=S(NC1=CC=C(F)C(C(C2=CNC3=NC=C(C4=CN=C(C5CC5)N=C4)C=C32)=O)=C1F)(N(CC)C)=O
Molecular Formula
C24H22F2N6O3S
Molecular Weight
512.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Zhang C, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526 (7574) :583-586.|[2]Basile KJ, et al. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res. 2014 May;27 (3) :479-84|[3]Le K, et al. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells. Pigment Cell Melanoma Res. 2013 Jul;26 (4) :509-17
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf
Available Sizes
Curated Selection
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