SL 0101-1

SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta, is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC50 of 89 nM[1]. SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a Ki of 1 μM[2].

Product Specifications

CAS Number

[77307-50-7]

Product Name Alternative

SL0101

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ribosomal S6 Kinase (RSK)

Type

Natural Products

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SL_0101-1.html

Purity

98.0

Solubility

DMSO : 10 mg/mL (ultrasonic; warming)

Smiles

OC1=CC(O)=C(C(C(O[C@@H]2O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1

Molecular Formula

C25H24O12

Molecular Weight

516.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65 (3) :1027-34.|[2]Yu Li, et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4'-hydroxy. Chem Commun (Camb) . 2020 Mar 10;56 (20) :3058-3060.