CBL0137 (hydrochloride)

CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 μM, respectively.

Product Specifications

CAS Number

[1197397-89-9]

Product Name Alternative

Curaxin-137 (hydrochloride) ; CBL-C137 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MDM-2/p53; NF-κB

Type

Reference compound

Related Pathways

Apoptosis; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/CBL0137_hydrochloride.html

Purity

99.72

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 10 mg/mL (ultrasonic)

Smiles

CC(NCCN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C.[H]Cl

Molecular Formula

C21H25ClN2O2

Molecular Weight

372.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Burkhart C, et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget. 2014 Nov 30;5 (22) :11038-53.|[2]Gasparian AV, et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med. 2011 Aug 10;3 (95) :95ra74.