N-1518
N-1518 is an α and β adrenergic receptor blocker that has competitive antagonism against β1 and α1 receptors, but does not show selectivity for β1 receptors, but shows about 20-fold selectivity for α1 receptors. N-1518 has vasodilatory effects and can be used in the research field of hypertension treatment[1].
Product Specifications
CAS Number
93750-14-2
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/n-1518.html
Smiles
O=C1NC=C(C2=C1C=CC=C2)OCC(CNC(COC3=C(OC)C=CC=C3)C)O
Molecular Formula
C22H26N2O5
Molecular Weight
398.45
References & Citations
[1]T Sugai, et al. [Pharmacological properties of (+/-) -4-[2-hydroxy-3- (3- (2-methoxyphenoxy) -2-propylamino) propoxy]-1 (2H) -isoquinolinone (N-1518), a new combined alpha-and beta-adrenoceptor blocking drug]. Nihon Yakurigaku zasshi. Folia Pharmacologica Japonica 96.3 (1990) : 117-127.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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