8-M-PDOT
8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].
Product Specifications
CAS Number
134865-70-6
Product Name Alternative
AH-002
UNSPSC
12352005
Target
Melatonin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/8-m-pdot.html
Purity
99.33
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCC(NC1CC2=C(C=CC=C2OC)CC1)=O
Molecular Formula
C14H19NO2
Molecular Weight
233.31
References & Citations
[1]Browning C, et al. Pharmacological characterization of human recombinant melatonin mt (1) and MT (2) receptors. Br J Pharmacol. 2000 Mar;129 (5) :877-86.|[2]Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9 (1) :47-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MT2
Available Sizes
Frequently Asked Questions
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