8-M-PDOT

8-M-PDOT (AH-002) is a selective melatonin MT2 receptor agonist. 8-M-PDOT is 5.2-fold selective for MT2 over MT1 receptors. 8-M-PDOT binds human recombinant MT2 and MT2 receptors with pKi values of 8.23 and 8.95 respectively. 8-M-PDOT has anxiolytic-like activity[1][2].

Product Specifications

CAS Number

[134865-70-6]

Product Name Alternative

AH-002

UNSPSC

12352005

Target

Melatonin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/8-m-pdot.html

Purity

99.33

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCC(NC1CC2=C(C=CC=C2OC)CC1)=O

Molecular Formula

C14H19NO2

Molecular Weight

233.31

References & Citations

[1]Browning C, et al. Pharmacological characterization of human recombinant melatonin mt (1) and MT (2) receptors. Br J Pharmacol. 2000 Mar;129 (5) :877-86.|[2]Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9 (1) :47-54.