(R) -Baclofen

(R) -Baclofen (Arbaclofen) is a selective GABAB receptor agonist[1].

Product Specifications

CAS Number

[69308-37-8]

Product Name Alternative

Arbaclofen; STX209

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/_R_-Baclofen.html

Purity

99.50

Solubility

DMSO : 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 5 mg/mL (ultrasonic)

Smiles

ClC1=CC=C([C@](CC(O)=O)([H])CN)C=C1

Molecular Formula

C10H12ClNO2

Molecular Weight

213.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Hong YG, et al. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196 (3) :267-75.|[2]Falch E, et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47 (3) :898-903.|[3]Falch E, et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47 (3) :898-903.|[4]Orsnes G, et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111 (8) :1372-9.