(R) -Baclofen
(R) -Baclofen (Arbaclofen) is a selective GABAB receptor agonist[1].
Product Specifications
CAS Number
69308-37-8
Product Name Alternative
Arbaclofen; STX209
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-Baclofen.html
Purity
99.50
Solubility
DMSO : 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 5 mg/mL (ultrasonic)
Smiles
ClC1=CC=C([C@](CC(O)=O)([H])CN)C=C1
Molecular Formula
C10H12ClNO2
Molecular Weight
213.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Hong YG, et al. Effects of phaclofen and the enantiomers of baclofen on cardiovascular responses to intrathecal administration of L- and D-baclofen in the rat. Eur J Pharmacol. 1991 Apr 24;196 (3) :267-75.|[2]Falch E, et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47 (3) :898-903.|[3]Falch E, et al. Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations. J Neurochem. 1986 Sep;47 (3) :898-903.|[4]Orsnes G, et al. The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients. Clin Neurophysiol. 2000 Aug;111 (8) :1372-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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