KU-60019
KU-60019 is an improved ATM kinase-specific inhibitor with IC50 of 6.3 nM.
Product Specifications
CAS Number
925701-46-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/KU-60019.html
Purity
99.43
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic)
Smiles
C[C@@H]1O[C@@H](CN(CC(NC2=CC3=C(C=C2)SC4=C(C3)C=CC=C4C5=CC(C=C(O5)N6CCOCC6)=O)=O)C1)C
Molecular Formula
C30H33N3O5S
Molecular Weight
547.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Golding SE, et al. Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion. Mol Cancer Ther. 2009 Oct;8 (10) :2894-902.|[2]McCabe N, et al. Mechanistic Rationale to Target PTEN-Deficient Tumor Cells with Inhibitors of the DNA Damage Response Kinase ATM. Cancer Res. 2015 Jun 1;75 (11) :2159-65.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
Available Sizes
Frequently Asked Questions
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