PKC-theta inhibitor 2
PKC-theta inhibitor 2 is a potent and selective PKC-θ inhibitor with an IC50 value of 18 nM[1].
Product Specifications
CAS Number
736048-65-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/PKC-theta_inhibitor.html
Purity
99.88
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
FC(F)(F)OC1=CC=CC=C1CNC2=NC=C([N+]([O-])=O)C(NCC3CCC(CN)CC3)=N2
Molecular Formula
C20H25F3N6O3
Molecular Weight
454.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Cywin CL, et al. Discovery of potent and selective PKC-theta inhibitors. Bioorg Med Chem Lett. 2007 Jan 1;17 (1) :225-30.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKCθ
Available Sizes
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