Gigantol isomer-1

Gigantol isomer-1 is a bibenzyl compound derived from Dendrobium nobile. Gigantol isomer-1 shows promising therapeutic potential against cancer cells. Gigantol isomer-1 is a novel inhibitor of the Wnt/β-catenin pathway.

Product Specifications

CAS Number

[67884-30-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Wnt

Type

Natural Products

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gigantol-isomer-1.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 50 mg/mL (ultrasonic)

Smiles

COC1=CC(O)=CC(CCC2=CC(O)=C(OC)C=C2)=C1

Molecular Formula

C16H18O4

Molecular Weight

274.32

Precautions

H302, H315, H319

References & Citations

[1]Yu S, et al. Gigantol inhibits Wnt/β-catenin signaling and exhibits anticancer activity in breast cancer cells. BMC Complement Altern Med. 2018 Feb 14;18 (1) :59.|[2]Chen H, et al. Gigantol attenuates the proliferation of human liver cancer HepG2 cells through the PI3K/Akt/NF-κB signaling pathway. Oncol Rep. 2017 Feb;37 (2) :865-870.|[3]Déciga-Campos M, et al. Antinociceptive and anti-inflammatory effects of compounds isolated from Scaphyglottis livida and Maxillaria densa. J Ethnopharmacol. 2007 Nov 1;114 (2) :161-8.