Sofosbuvir
Sofosbuvir (GS-7977) is an HCV RNA replication inhibitor with an EC50 of 92 nM[1].
Product Specifications
CAS Number
1190307-88-0
Product Name Alternative
GS-7977; PSI-7977
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/PSI-7977.html
Purity
99.99
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic; warming; heat to 50°C)
Smiles
C[C@@]1(F)[C@H](O)[C@@H](CO[P@](OC2=CC=CC=C2)(N[C@@H](C)C(OC(C)C)=O)=O)O[C@H]1N(C=CC(N3)=O)C3=O
Molecular Formula
C22H29FN3O9P
Molecular Weight
529.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Murakami E, et al.
 Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977.J Biol Chem. 2010 Nov 5;285 (45) :34337-47.|[2]Lam AM, et al.
 Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus.
 Antimicrob Agents Chemother. 2012 Jun;56 (6) :3359-68.|[3]Sofia MJ, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem. 2010 Oct 14;53 (19) :7202-18.|[4]Zhang X, et al. Discovery and evolution of aloperine derivatives as a new family of HCV inhibitors with novel mechanism. Eur J Med Chem. 2018 Jan 1;143:1053-1065.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
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Available Sizes
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