YM218 (free base)
YM218 free base is an orally active non-peptide vasopressin (AVP) receptor antagonist. YM218 free base has a high affinity for rat liver V1A receptors with a Ki value of 0.50 nM; it has a lower affinity for rat pituitary V1B, kidney V2, and uterine oxytocin receptors with Ki values of 1510 nM, 72.2 nM, and 150 nM, respectively. YM218 free base can be used in the study of diabetes and kidney disease[1].
Product Specifications
CAS Number
[387816-81-1]
UNSPSC
12352005
Target
Vasopressin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ym218-free-base.html
Smiles
O=C(NC1=CC=C(C=C1)C(N2CCC(F)(/C(C3=CC=CC=C32)=C\C(N4CCC(CC4)N5CCCCC5)=O)F)=O)C6=C(OC=C6)C
Molecular Formula
C35H38F2N4O4
Molecular Weight
616.70
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
V1a Receptor ; V1b Receptor ; V2 Receptor
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
DRAM1, CT (DRAM, DNA Damage-regulated Autophagy Modulator Protein 1, Damage-regulated Autophagy Modulator) discontinued. see D9370
Lentiviral mouse Khdc1a shRNA (UAS) - Lentiviral mouse Khdc1a shRNA (UAS) (100)
