PSB-12379
PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human) [1][2].
Product Specifications
CAS Number
1802226-78-3
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
CD73
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PSB-12379.html
Concentration
10mM
Purity
99.96
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O
Molecular Formula
C18H23N5O9P2
Molecular Weight
515.35
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Bhattarai S, et al. α, β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58 (15) :6248-63.|[2]X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 -Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Sanjay Bhattarai. Adv. Therap. 2019, 2, 1900075.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
GM-07-15 1 mL
Colloidal Gold Conjugated Monoclonal Antibody to Human IgG, 15nm
Sign In for Pricing
View Details 
![WDR74 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4F2]](https://cdn.genprice.uk/products/937/68dd1b75061270361ea1a152/imageurl/ta800440am.webp)
TA800440AM 100 µL
WDR74 Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI4F2]
Sign In for Pricing
View Details 
BNC042590-100 1x 100 µL
CD10 (Membrane Metalloendopeptidase) (MME/2590), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![NAPSIN A (NAPSA) Mouse Monoclonal Antibody [Clone ID: OTI2F11]](https://cdn.genprice.uk/products/937/68dd18b9061270361e908218/imageurl/cf807998.webp)
CF807998 100 µg
NAPSIN A (NAPSA) Mouse Monoclonal Antibody [Clone ID: OTI2F11]
Sign In for Pricing
View Details