PSB-12379

PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human) [1][2].

Product Specifications

CAS Number

[1802226-78-3]

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

CD73

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PSB-12379.html

Concentration

10mM

Purity

99.96

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=P(O)(O)CP(OC[C@H]1O[C@@H](N2C=NC3=C(NCC4=CC=CC=C4)N=CN=C32)[C@H](O)[C@@H]1O)(O)=O

Molecular Formula

C18H23N5O9P2

Molecular Weight

515.35

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Bhattarai S, et al. α, β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58 (15) :6248-63.|[2]X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 -Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy Sanjay Bhattarai. Adv. Therap. 2019, 2, 1900075.