KY-02327 (acetate)
KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl) -CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation[1].
Product Specifications
CAS Number
[2989396-34-9]
UNSPSC
12352005
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ky-02327-acetate.html
Purity
99.24
Solubility
DMSO : 140 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : ≥ 160 mg/mL
Smiles
O=C(C(N1CC(NCCN2CCCCC2)=O)=CC3=C1C=CC(O)=C3)OCC.CC(O)=O
Molecular Formula
C22H31N3O6
Molecular Weight
433.50
References & Citations
[1]Kim HY, et al. Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Mol Med. 2016;8 (4) :375-387.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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