KY-02327 (acetate)

KY-02327 acetate, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl) -CXXC5 interaction inhibitor. KY-02327 acetate shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation[1].

Product Specifications

CAS Number

[2989396-34-9]

UNSPSC

12352005

Target

Wnt

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/ky-02327-acetate.html

Purity

99.24

Solubility

DMSO : 140 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : ≥ 160 mg/mL

Smiles

O=C(C(N1CC(NCCN2CCCCC2)=O)=CC3=C1C=CC(O)=C3)OCC.CC(O)=O

Molecular Formula

C22H31N3O6

Molecular Weight

433.50

References & Citations

[1]Kim HY, et al. Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Mol Med. 2016;8 (4) :375-387.