(R, R) -CXCR2-IN-2

(R, R) -CXCR2-IN-2, diastereoisomer of CXCR2-IN-2 (compound 68), is a brain penetrant CXCR2 antagonist with a pIC50 of 9 and 6.8 in the Tango assay and d in the HWB Gro-α induced CD11b expression assay, respectively[1].

Product Specifications

CAS Number

[1838123-22-0]

UNSPSC

12352005

Target

CXCR

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/r-r-cxcr2-in-2.html

Concentration

10mM

Purity

99.37

Solubility

DMSO : 220 mg/mL (ultrasonic)

Smiles

O=S(C1=C(C(NC(N[C@H]2C(C)=CCC2)=O)=CC=C1Cl)O)([C@@]3(CCOC3)C)=O

Molecular Formula

C18H23ClN2O5S

Molecular Weight

414.90

References & Citations

[1]Lu H, et al. Discovery of Novel 1-Cyclopentenyl-3-phenylureas as Selective, Brain Penetrant, and Orally Bioavailable CXCR2 Antagonists. J Med Chem. 2018;61 (6) :2518-2532.