EGFR ligand-11
EGFR ligand-11 is a target protein ligand for EGFR and can be used to synthesize PROTAC MS154 (HY-141640) [1].
Product Specifications
CAS Number
[2550394-08-4]
UNSPSC
12352005
Target
EGFR; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-ligand-11.html
Smiles
FC(C(Cl)=C1)=CC=C1NC2=C(C(C=C3OC)=NC=N2)C=C3OCCCN4CCN(CCC(O)=O)CC4
Molecular Formula
C25H29ClFN5O4
Molecular Weight
517.98
References & Citations
[1]Meng Cheng, et al. Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-molecule Degraders. J Med Chem. 2020 Feb 13;63 (3) :1216-1232.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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