A1899

A1899 is a potent and highly selective blocker of the K2P channel TASK-1. A1899 has IC50 values of 35.1 nM and 7 nM for TASK-1 channels expressed in oocytes and CHO cells, respectively. A1899 is also an IKur blocker that can be used for the research of cardiovascular diseases[1][2].

Product Specifications

CAS Number

[498577-46-1]

Product Name Alternative

S20951

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Potassium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/a1899.html

Purity

99.72

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C(C=C1F)F)C2=CC=CC=C2C3=CC=CC=C3CNC(CC4=CC=C(C=C4)OC)=O

Molecular Formula

C30H26F2N2O3

Molecular Weight

500.54

Precautions

H302, H315, H319

References & Citations

[1]Streit AK, et al. A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore. J Biol Chem. 2011 Apr 22;286 (16) :13977-84. |[2]Knobloch K, et al. Electrophysiological and antiarrhythmic effects of the novel I (Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I (Kr) blockers dofetilide, azimilide, d, l-sotalol and ibutilide. Naunyn Schmiedebergs Arch Pharmacol. 2002 Nov;366 (5) :482-7.